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Repetitive Spreading Depolarization induces gene expression changes related to synaptic plasticity and

Michela Dell'Orco1, Jordan E Weisend1, Nora I Perrone-Bizzozero1

  • 1Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, 87131, USA.

Biorxiv : the Preprint Server for Biology
|March 13, 2023
PubMed
Summary

Spreading depolarization (SD) activates beneficial cell survival and plasticity pathways, not just damage. Gene expression analysis reveals compensatory mechanisms and potential therapeutic targets in brain tissue.

Keywords:
brain injurygene expressionpathway analysispreconditioningspreading depressionstroke

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