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Bladder cancer following low or high dose pelvic irradiation
1Department of Clinical Oncology, Western General Hospital, Edinburgh.
Clinical Radiology
|November 1, 1987
Summary
Previous pelvic irradiation increases bladder cancer risk, particularly high-grade, advanced tumors. Longer intervals between low-dose radiation and cancer diagnosis were observed compared to high-dose exposure.
Area of Science:
- Oncology
- Radiation Oncology
- Urologic Oncology
Background:
- Pelvic irradiation is a known risk factor for secondary malignancies.
- Bladder cancer can develop years after radiation therapy for other pelvic conditions.
Purpose of the Study:
- To investigate the characteristics and outcomes of bladder cancer in women with a history of pelvic irradiation.
- To analyze the relationship between radiation dose and the latency period for bladder cancer development.
Main Methods:
- Retrospective case series of 11 women with bladder cancer and prior pelvic irradiation.
- Analysis of tumor grade, T-category, survival rates, and time intervals from irradiation to diagnosis.
Main Results:
- All tumors were high-grade and advanced T-category.
- One-year survival rate was poor at 32%.
- The mean interval to bladder cancer was 30 years after low-dose irradiation versus 16.5 years after high-dose irradiation.
Conclusions:
- Pelvic irradiation is associated with a poor prognosis for subsequent bladder cancer.
- Lower radiation doses may have a longer latency period for bladder cancer development compared to higher doses.