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Updated: Aug 7, 2025
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Transduction and Expansion of Primary T Cells in Nine Days with Maintenance of Central Memory Phenotype
Published on: March 18, 2020
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Drug-tolerant persister B-cell precursor acute lymphoblastic leukemia cells
Biorxiv : the Preprint Server for Biology
|March 13, 2023
Summary
Chemotherapy-resistant precursor B-acute lymphoblastic leukemia (BCP-ALL) cells survive by utilizing bone marrow stromal cells. Key genes in autophagy and p53 pathways, along with CD44 and ABCC1, are crucial for this drug resistance and minimal residual disease (MRD) persistence.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Reduced responsiveness to chemotherapy in precursor B-acute lymphoblastic leukemia (BCP-ALL) is indicated by persistent leukemia cells after 28 days of treatment.
- Bone marrow stromal cells protect these long-term persister (LTP) or minimal residual disease (MRD) cells during chemotherapy stress.
Conclusions:
- Autophagy, lysosomal function, and the p53 pathway are critical for BCP-ALL cell survival and drug resistance.
- Specific genes like MYH9, NCSTN, KIAA2013, CD44, and the drug transporter ABCC1 play roles in maintaining BCP-ALL cell fitness and surviving vincristine treatment.
- Inhibiting ABCC1 during vincristine therapy may improve the eradication of minimal residual disease in BCP-ALL patients.
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