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Gastrointestinal non-Hodgkin's lymphoma.

A R Makepeace1, D C Fermont, M H Bennett

  • 1Meyerstein Institute of Radiotherapy and Oncology, Middlesex Hospital, London.

Clinical Radiology
|November 1, 1987
PubMed
Summary

This study reviewed 72 gastrointestinal non-Hodgkin's lymphoma cases from 1952-1980. Most patients had Grade 2 lymphoma, with low 5-year survival rates indicating a need for improved treatment strategies.

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Area of Science:

  • Oncology
  • Gastroenterology
  • Hematology

Background:

  • Gastrointestinal non-Hodgkin's lymphoma (GI-NHL) is a rare malignancy.
  • Treatment strategies and outcomes for GI-NHL have evolved over time.
  • Understanding historical treatment patterns is crucial for evaluating current therapeutic approaches.

Purpose of the Study:

  • To review treatment outcomes for gastrointestinal non-Hodgkin's lymphoma patients treated between 1952 and 1980.
  • To analyze the distribution of lymphoma involvement in the gastrointestinal tract.
  • To assess the impact of different treatment modalities on survival and relapse rates.

Main Methods:

  • Retrospective review of 72 patients diagnosed with gastrointestinal non-Hodgkin's lymphoma.
  • Analysis of treatment modalities including surgical resection, radiotherapy, and chemotherapy.
  • Histological review using British National Lymphoma Investigation criteria.
  • Evaluation of overall and relapse-free survival rates at 5 years.

Main Results:

  • The small intestine was involved in 49% of cases, and the stomach in 29%.
  • Overall 5-year survival was 36%, with a 5-year relapse-free survival of 22%.
  • Fifty-seven percent of patients relapsed, and 80% of those relapsed patients died from lymphoma.
  • 94% of cases were reclassified as Grade 2 non-Hodgkin's lymphoma.

Conclusions:

  • Gastrointestinal non-Hodgkin's lymphoma historically had poor survival outcomes.
  • Treatment approaches varied based on disease extent and resectability.
  • The high relapse rate underscores the need for more effective therapeutic strategies for GI-NHL.

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