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Olfactory inputs to appetite neurons in the hypothalamus.
The sense of smell influences appetite by sending odor signals to brain appetite control neurons. Different odor pathways and neuromodulators can uniquely control appetite-promoting and appetite-suppressing neurons.
Area of Science:
- Neuroscience
- Olfactory system
- Appetite regulation
Background:
- The neural basis of how smell impacts appetite remains largely unknown.
- The hypothalamic arcuate nucleus houses AgRP (agouti-related peptide) neurons that enhance appetite and POMC (pro-opiomelanocortin) neurons that suppress appetite.
Conclusions:
- Higher olfactory areas differentially modulate appetite-regulating neurons in the hypothalamus.
- Subsets of AgRP neurons are uniquely regulated by distinct neuromodulators.
- Specific neuronal populations upstream of AgRP neurons utilize varied neuromodulator combinations to influence appetite.
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