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Updated: Aug 7, 2025

Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance
05:23

Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance

Published on: March 7, 2025

454

Comparison of multiple treatment regimens in children with Helicobacter pylori infection: A network meta-analysis

Miaomiao Liang1,2, Chengbi Zhu1,2, Peipei Zhao1,2

  • 1Department of Pediatrics, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.

Frontiers in Cellular and Infection Microbiology
|March 13, 2023
PubMed

Insights

Sequential therapy with probiotics (SP) is the most effective and safest treatment for childhood Helicobacter pylori eradication. This finding offers crucial guidance for pediatric H. pylori treatment strategies globally.

Area of Science:

  • Pediatric Gastroenterology
  • Infectious Diseases
  • Evidence-Based Medicine

Background:

  • Helicobacter pylori infection is common in children worldwide.
  • Various treatment regimens exist, but comparative effectiveness data is limited.
  • Understanding optimal eradication strategies is crucial for pediatric health.

Purpose of the Study:

  • To compare the efficacy and safety of different Helicobacter pylori eradication regimens in children.
  • To identify the most effective and safest treatment strategies based on global data.

Main Methods:

  • Systematic review and meta-analysis of randomized controlled trials.
  • Involved 163 studies with 18,257 children and 10 interventions.
  • Statistical analysis using Review Manager, Stata, and R; ranking by SUCRA.

Main Results:

  • Sequential therapy with probiotics (SP) demonstrated the highest eradication rate (SUCRA 92.7%).
  • Bismuth-containing triple therapy had the lowest eradication rate (SUCRA 3.5%).
  • SP and Triple therapy with probiotics (TP) showed superior safety profiles.

Conclusions:

  • Sequential therapy with probiotics (SP) is the leading regimen for pediatric H. pylori eradication.
  • SP and TP therapies are recommended for their high efficacy and safety in children.
Abstract

Keywords:
Helicobacter pylorichildrenefficacynetwork meta-analysistreatment regimens

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