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Updated: Aug 7, 2025
A Model to Simulate Clinically Relevant Hypoxia in Humans
Published on: December 22, 2016
Association between simulated ketamine exposures and oxygen saturations in children
Sarah Jane Commander1,2, Daniel Gonzalez3, Karan R Kumar1,4
1Duke Clinical Research Institute, Duke University, Durham, NC 27705, USA.
Aim:
We performed a real-world data analysis to evaluate the relationship between simulated ketamine exposures and oxygen desaturation in children.
Materials & Methods:
A previously developed population pharmacokinetic model was used to simulate exposures and evaluate target attainment, as well as the association with oxygen desaturation in children ≤17 years treated with intravenous ketamine.
Results:
In 2022 children, there was no significant association between simulated plasma ketamine concentrations and oxygen saturation; however, a higher cumulative area under the curve was associated with increased odds of progression to significant desaturation (<85%), though magnitude of effect was small.
Conclusion:
By leveraging a population pharmacokinetic model and real-world data, we confirmed there is no relationship between simulated ketamine plasma concentration and oxygen desaturation.
