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Updated: Aug 7, 2025
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A Colorimetric Assay that Specifically Measures Granzyme B Proteolytic Activity: Hydrolysis of Boc-Ala-Ala-Asp-S-Bzl
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Granzyme B Gene Polymorphisms Are Associated With Severe Non-segmental Vitiligo.
Abd El-Aziz El-Taweel1, Amira Abdelrahman2, Hebatallah Hegazy3
1Dr. El-Taweel is with Faculty of Medicine at 6th of October University in Cairo, Egypt.
The Journal of Clinical and Aesthetic Dermatology
|March 13, 2023
Summary
Genetic variations in the Granzyme B (GZMB) gene are linked to vitiligo development and disease severity in Egyptians. These GZMB polymorphisms may help predict extensive forms of vitiligo.
Area of Science:
- Immunogenetics
- Dermatology
- Human Genetics
Background:
- Granzyme B (GZMB) gene plays a role in human immunity.
- GZMB is implicated in the pathogenesis of vitiligo.
Purpose of the Study:
- To investigate the association between GZMB gene polymorphisms (R55Q and P94Q) and vitiligo in Egyptian patients.
- To determine if these polymorphisms correlate with disease severity.
Main Methods:
- A case-control study involving 100 vitiligo patients and 100 healthy controls.
- Genotyping of GZMB gene polymorphisms (R55Q and P94A) using polymerase chain reaction.
Main Results:
- Both GZMB P94Q and R55Q polymorphisms showed a significant association with higher Vitiligo Area and Severity Index (VASI) scores.
- The study identified specific GZMB variants linked to disease extent.
Conclusions:
- GZMB gene polymorphisms (Q55R and P94A) are associated with susceptibility to vitiligo in the Egyptian population.
- These genetic markers may aid in predicting more extensive forms of vitiligo.
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