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Hormones and Bone Tissue

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Related Experiment Video

Updated: Aug 7, 2025

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

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Published on: July 14, 2023

Does Etelcalcetide reverse myelofibrotic bone changes due to hyperparathyroidism? A case report.

Vincenzo Antonio Panuccio^1,2, Rocco Tripepi², Adele Postorino¹

¹Nephrology, Dialysis and Transplantation Unit, Grande Ospedale Metropolitano Bianchi-Melacrino-Morelli, Reggio Calabria, Italy.

Frontiers in Medicine

|March 13, 2023

Summary

Secondary hyperparathyroidism (SHPT) in dialysis patients is common. Etelcalcetide treatment improved SHPT and severe myelofibrosis, normalizing blood counts and bone marrow.

Keywords:

Etelcalcetide bone change dialysis (ESKD)hyperparatiroidism myelofibrosis

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Area of Science:

Nephrology
Hematology
Endocrinology

Background:

Secondary hyperparathyroidism (SHPT) is prevalent in patients undergoing chronic hemodialysis.
Severe SHPT can lead to complications, including bone marrow abnormalities.

Observation:

A hemodialysis patient with SHPT developed pancytopenia and resistant anemia.
Bone marrow biopsy revealed grade 3 fibrosis, osteosclerosis, and reduced myelopoiesis.

Findings:

Etelcalcetide treatment improved SHPT and normalized blood counts.
Repeat bone marrow biopsy showed resolution of myelofibrosis and improved bone marrow cellularity.

Implications:

Etelcalcetide offers a potential therapeutic option for SHPT with associated myelofibrosis.
This case suggests Etelcalcetide may be an alternative to parathyroidectomy for managing SHPT and its hematologic sequelae.