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Association of the IL-4R Q576R Polymorphism with Pediatric Asthma: a meta-analysis

Xiwu Chen¹, Jinhui Hu¹, Kaiwei Li¹

¹Department of Pediatrics, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Edong Healthcare Group, Huangshi, Hubei 435000, China.

African Health Sciences

|March 13, 2023

Abstract

Background:

The relationship between Q576R polymorphism of IL-4 receptor (IL-4R) gene and pediatric asthma risk is still undefined. To this end, this meta-analysis was performed to explore the above controversy.

Methods:

In this study, we systemically retrieved CNKI, EMBASE, Web of Science, Scopus, Science direct and Pub Med to collect relevant researches, followed by calculation of odds ratio (OR) along with 95% confidence intervals (CIs). STATA 12.0 software was employed in this meta-analysis.

Results:

We found an association between IL-4R Q576R polymorphism and pediatric asthma risk (GG vs AA: OR = 3.75, 95% CI = 1.89-7.45; AG vs AA: OR = 2.15, 95% CI = 1.36-3.39; the dominant model: OR = 2.25, 95% CI = 1.42-3.57;the recessive model: OR = 3.05, 95% CI = 1.54-6.05). Moreover, there was no obvious publication bias.

Conclusion:

Our findings suggested that G allele of IL-4R Q576R polymorphism is associated with increased risk of pediatric asthma. Anyhow, delicately-designed, large-scale studies should be conducted to further confirm the current outcomes.

Keywords:

Asthma IL-4 Meta-analysis

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