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The role of childhood trauma in patients with chronic urticaria

Neslihan Cansel1, Dursun Turkmen2, Nihal Altunisik2

  • 1Department of Psychiatry, Inonu University Faculty of Medicine, Malatya, Turkiye.

Northern Clinics of Istanbul
|March 13, 2023
PubMed

Insights

Childhood trauma is linked to chronic urticaria (CU), increasing disease severity and early onset. This association also extends to higher rates of anxiety and depression in CU patients.

Area of Science:

  • Psychodermatology
  • Immunology
  • Psychotraumatology

Background:

  • Chronic urticaria (CU) involves immunological and psychological factors.
  • Childhood trauma may disrupt neuro-immuno-cutaneous-endocrine development, potentially leading to skin diseases like CU.
  • Investigating the link between childhood trauma and CU is crucial for understanding disease etiology.

Purpose of the Study:

  • To explore the potential relationship between childhood traumatic experiences and Chronic Urticaria (CU).
  • To determine if childhood trauma influences the onset and severity of CU.
  • To assess the correlation between childhood trauma and psychological comorbidities in CU patients.

Main Methods:

  • A case-control study involving 50 CU patients and 53 controls.
  • Participants completed questionnaires on sociodemographics, anxiety (Beck Anxiety Scale), depression (Beck Depression Scale), and childhood trauma (Childhood Trauma Questionnaire-28).

Main Results:

  • Childhood trauma was more prevalent in CU patients (68%) than controls (54.7%).
  • CU patients exhibited higher scores for moderate to severe anxiety and depression.
  • Emotional abuse scores were higher in early-onset CU (<35 years), and depression/anxiety scores correlated with various trauma types.

Conclusions:

  • Childhood traumas are significantly associated with Chronic Urticaria (CU).
  • Trauma is linked to earlier onset and increased severity of CU.
  • Childhood trauma contributes to the psychological comorbidities, including depression and anxiety, observed in CU patients.
Abstract

Keywords:
Anxietychildhood abusechronic urticariadepressionneglect

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