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Case series: expanding diagnostic markers in postorgasmic illness syndrome
Leah Rosetti1, Amin Kanani2, Luke Witherspoon3,4
1Department of Psychiatry, University of British Columbia, 255 Wesbrook Mall, Vancouver, BC V6T 2A1, Canada.
Introduction:
Postorgasmic illness syndrome (POIS) is a rare condition in which individuals develop generalized and flu-like symptoms after ejaculation. Several mechanisms and treatments for this disorder have been proposed but many questions remain.
Aims:
We sought to present a summary of literature to date and highlight common symptoms, associated features, comorbidities, and laboratory findings in a clinical sample of patients with POIS.
Methods:
We conducted a retrospective chart review of 6 patients with POIS in our clinic and presented compiled results.
Results:
We identified newly described non-flu-like presentations, onset of symptoms with high states of arousal without ejaculation, and presence of psychiatric comorbidity in a majority of patients. We did not identify a postorgasm allergic response with bloodwork available.
Conclusion:
POIS remains a poorly understood condition that likely comprises a number of different clinical entities. Further research on a larger clinical sample is necessary to better characterize POIS and understand its biological and psychological basis.
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