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NI-BODIPY-GO Nanocomposites for Targeted PDT
Ezel Öztürk Gündüz1, Berkan Tasasız1, M Emre Gedik2
1Department of Chemistry, Faculty of Science, Gebze Technical University, Gebze, Kocaeli 41400, Turkey.
ACS Omega
|March 13, 2023
Summary
Novel targeted NI-BODIPY nanocarriers were developed for cancer therapy. Graphene oxide (GO) enhanced singlet oxygen production and cancer cell killing efficacy without dark toxicity.
Area of Science:
- Nanotechnology
- Materials Science
- Biomedical Engineering
Background:
- Development of targeted nanocarriers for cancer therapy is crucial.
- NI-BODIPY dyes offer potential as photosensitizers for photodynamic therapy.
- Graphene oxide (GO) is a promising nanomaterial for drug delivery and diagnostics.
Purpose of the Study:
- To fabricate and characterize multifunctional targeted NI-BODIPY/GO nanocarriers.
- To investigate the photophysical and photochemical properties of these nanocarriers.
- To evaluate their efficacy in vitro for cancer cell killing.
Main Methods:
- Synthesis and characterization of NI-BODIPY dyes (10-12) and GO-(10-12) nanocarriers.
- Detailed photophysical and photochemical property analysis.
- In vitro evaluation of singlet oxygen generation and cancer cell (K562) killing efficacy.
Main Results:
- Successful fabrication of multifunctional targeted NI-BODIPY/GO nanocarriers.
- Favorable interactions between GO and NI-BODIPY dyads, enhancing singlet oxygen formation.
- Significant in vitro cancer cell killing efficacy with no observed dark toxicity.
Conclusions:
- NI-BODIPY/GO nanocarriers are effective theranostic agents.
- GO enhances the photodynamic therapy potential of NI-BODIPY dyes.
- These nanocarriers show promise for targeted cancer treatment.
