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Updated: Aug 7, 2025

A Pilot Study on the Repetitive Transcranial Magnetic Stimulation of Aβ and Tau Levels in Rhesus Monkey Cerebrospinal Fluid
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Chronic caffeine consumption curbs rTMS-induced plasticity.

Megan Vigne1, Jamie Kweon1, Prayushi Sharma1

  • 1Neuromodulation Research Facility, TMS Clinic, Butler Hospital, Providence, RI, United States.

Frontiers in Psychiatry
|March 13, 2023
PubMed
Summary
This summary is machine-generated.

Chronic caffeine consumption may impair brain plasticity and reduce the effectiveness of learning and memory interventions like repetitive transcranial magnetic stimulation (rTMS). Further research is needed to confirm these findings.

Keywords:
caffeined-cycloserinelong-term potentiationmotor evoked potentialsplasticitytranscranial magnetic stimulation

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Area of Science:

  • Neuroscience
  • Psychopharmacology

Background:

  • Caffeine is a common psychostimulant that antagonizes adenosine receptors (A1 and A2A) in the brain.
  • Adenosine receptors modulate long-term potentiation (LTP), a key mechanism for learning and memory.
  • Repetitive transcranial magnetic stimulation (rTMS) is believed to induce LTP and alter cortical excitability.

Purpose of the Study:

  • To investigate the impact of chronic caffeine use on brain plasticity.
  • To examine if caffeine consumption affects the efficacy of rTMS-induced corticomotor plasticity.

Main Methods:

  • A secondary analysis was performed on data from two prior studies involving 10 Hz rTMS and D-cycloserine (DCS).
  • The study included twenty healthy subjects.
  • Motor evoked potentials (MEPs) were used to measure corticomotor excitability and plasticity.

Main Results:

  • Non-caffeine users showed enhanced motor evoked potential (MEP) facilitation compared to both caffeine users and placebo groups.
  • This suggests that chronic caffeine intake may attenuate neuroplasticity.

Conclusions:

  • Preliminary findings indicate that chronic caffeine use might hinder learning and plasticity.
  • Further well-powered prospective studies are recommended to validate these results and explore caffeine's effects on rTMS effectiveness.