Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Improving Translational Accuracy02:07

Improving Translational Accuracy

11.7K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
11.7K
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

19.0K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
19.0K
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

2.5K
2.5K
Mismatch Repair01:36

Mismatch Repair

40.5K
Overview
40.5K
Genome Copying Errors02:46

Genome Copying Errors

4.3K
DNA replication is a well-evolved process that copies millions of base pairs with high fidelity during each cell division. Occasionally a wrong base or a long stretch of wrong bases may get added to the daughter strands. If the errors are left unchecked, cells might accumulate several mutations that might endanger their  survival. Therefore, the copying errors are checked and repaired at three levels.
4.3K
Spreading of Chromatin Modifications02:25

Spreading of Chromatin Modifications

8.3K
The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer...
8.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A network database for the human biobank.

Advanced genetics (Hoboken, N.J.)·2023
Same author

The missing person in gene-environment interactions.

Advanced genetics (Hoboken, N.J.)·2023
Same author

Reading and writing genomes.

Advanced genetics (Hoboken, N.J.)·2023
Same author

Addendum: The FAIR Guiding Principles for scientific data management and stewardship.

Scientific data·2019
Same author

FAIR to the community.

Nature genetics·2018
Same author

The FAIR Guiding Principles for scientific data management and stewardship.

Scientific data·2016
Same journal

PDMSA: A Web-Based Tool for Pan-Cancer Survival Analysis Using DNA Methylation Levels as Biomarkers.

Advanced genetics (Hoboken, N.J.)·2026
Same journal

Antioxidation is a Common Defense Strategy for Different Species Under Mechanical Stress.

Advanced genetics (Hoboken, N.J.)·2026
Same journal

From Disease-Specific Models to Broad Clinical Utility: A Perspective on AI Hybrid Ensemble Frameworks.

Advanced genetics (Hoboken, N.J.)·2026
Same journal

Front Cover: PDMSA: A Web-Based Tool for Pan-Cancer Survival Analysis Using DNA Methylation Levels as Biomarkers (Advanced Genetics 2/07).

Advanced genetics (Hoboken, N.J.)·2026
Same journal

RNAi-Based Pesticides: Genetic Innovations for Sustainable Crop Protection and One Health.

Advanced genetics (Hoboken, N.J.)·2026
Same journal

Ciliary Defects in Inherited Retinal Diseases.

Advanced genetics (Hoboken, N.J.)·2026
See all related articles

Related Experiment Video

Updated: Aug 7, 2025

Genome-wide Surveillance of Transcription Errors in Eukaryotic Organisms
09:30

Genome-wide Surveillance of Transcription Errors in Eukaryotic Organisms

Published on: September 13, 2018

9.6K

Erratum: Reading and writing genomes.

Myles Axton

    Advanced Genetics (Hoboken, N.J.)
    |March 13, 2023
    PubMed
    Summary
    This summary is machine-generated.

    This study corrects a previously published article DOI. The correction ensures accurate citation and referencing for future scientific research.

    More Related Videos

    Proofreading and DNA Repair Assay Using Single Nucleotide Extension and MALDI-TOF Mass Spectrometry Analysis
    11:08

    Proofreading and DNA Repair Assay Using Single Nucleotide Extension and MALDI-TOF Mass Spectrometry Analysis

    Published on: June 19, 2018

    9.8K
    Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms
    09:51

    Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms

    Published on: May 25, 2018

    34.2K

    Related Experiment Videos

    Last Updated: Aug 7, 2025

    Genome-wide Surveillance of Transcription Errors in Eukaryotic Organisms
    09:30

    Genome-wide Surveillance of Transcription Errors in Eukaryotic Organisms

    Published on: September 13, 2018

    9.6K
    Proofreading and DNA Repair Assay Using Single Nucleotide Extension and MALDI-TOF Mass Spectrometry Analysis
    11:08

    Proofreading and DNA Repair Assay Using Single Nucleotide Extension and MALDI-TOF Mass Spectrometry Analysis

    Published on: June 19, 2018

    9.8K
    Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms
    09:51

    Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms

    Published on: May 25, 2018

    34.2K

    Area of Science:

    • Geosciences
    • Geochemistry

    Context:

    • Correction of a published article DOI.
    • Ensuring accurate scientific record.

    Purpose:

    • To provide the correct Digital Object Identifier (DOI) for a scientific article.
    • To facilitate proper citation and retrieval of research.

    Summary:

    • The article DOI 10.1002/ggn2.10016 has been corrected.
    • This ensures the integrity of scientific literature.

    Impact:

    • Improved accuracy in scientific referencing.
    • Enhanced discoverability of the corrected research article.