Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lagging Strand Synthesis01:59

Lagging Strand Synthesis

53.6K
During replication, the complementary strands in double-stranded DNA are synthesized at different rates. Replication first begins on the leading strand. Replication starts later, occurs more slowly, and proceeds discontinuously on the lagging strand.
There are several major differences between synthesis of the leading strand and synthesis of the lagging strand. 1) Leading strand synthesis happens in the direction of replication fork opening, whereas lagging strand synthesis happens in the...
53.6K
Homologous Recombination02:31

Homologous Recombination

50.8K
The basic reaction of homologous recombination (HR) involves two chromatids that contain DNA sequences sharing a significant stretch of identity. One of these sequences uses a strand from another as a template to synthesize DNA in an enzyme-catalyzed reaction. The final product is a novel amalgamation of the two substrates. To ensure an accurate recombination of sequences, HR is restricted to the S and G2 phases of the cell cycle. At these stages, the DNA has been replicated already and the...
50.8K
The Replisome03:01

The Replisome

34.1K
DNA replication is carried out by a large complex of proteins that act in a coordinated matter to achieve high-fidelity DNA replication. Together this complex is known as the DNA replication machinery or the replisome.
The synthesis of the leading and lagging strands is a highly coordinated process. To explain this, the “Trombone model” was proposed by Bruce Alberts in 1980. The DNA loop formation starts when a primer is synthesized on the parent lagging strand. The loop grows with...
34.1K
Translesion DNA Polymerases02:10

Translesion DNA Polymerases

10.1K
Translesion (TLS) polymerases rescue stalled DNA polymerases at sites of damaged bases by replacing the replicative polymerase and installing a nucleotide across the damaged site. Doing so, TLS allows additional time for the cell to repair the damage before resuming regular DNA replication.
TLS polymerases are found in all three domains of life - archaea, bacteria, and eukaryotes. Of the different classes of TLS polymerases, members of the Y family are fitted with specialized structures that...
10.1K
Mismatch Repair01:36

Mismatch Repair

40.4K
Overview
40.4K
Next-generation Sequencing03:00

Next-generation Sequencing

91.8K
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
91.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Network analysis of anxiety and depression in college students with different levels of physical activity.

Scientific reports·2026
Same author

A disulfide-bridged single-stranded DNA nanotube for co-delivery of siRNA and chemotherapeutics in ovarian cancer therapy.

Frontiers in medicine·2026
Same author

The landscape for therapeutic cancer vaccines.

Nature reviews. Drug discovery·2026
Same author

Aspartate Transporter SLC1A3 Promotes Colorectal Cancer via MDM2-p53 Pathway and M2 Macrophage Polarization.

Cancer science·2026
Same author

Cytoplasmic RNase III Drosha controls lipogenesis by noncanonical regulation of SREBP1.

Molecular cell·2026
Same author

Nitrogen regulates starch biosynthesis and multiscale structural properties of Sorghum under low-light stress.

Food research international (Ottawa, Ont.)·2026
Same journal

miRNAProtPred: computational prediction of human miRNA binding based on seed complementarity and thermodynamic stability.

Frontiers in genetics·2026
Same journal

Enhancing cereal productivity via nitrogen use efficiency: from conventional breeding to modern genomics.

Frontiers in genetics·2026
Same journal

Transcriptomic analysis reveals FcγR-mediated phagocytosis as a key pathway for the anti-inflammatory action of <i>Polygonatum sibiricum</i> polysaccharides in loach.

Frontiers in genetics·2026
Same journal

A novel <i>ABO</i> splice site variant underlying the A<sub>3</sub> phenotype: immunogenetic basis and functional dissection.

Frontiers in genetics·2026
Same journal

Case Report: Identification of two novel <i>ALMS1</i> variants in a patient with a ciliopathy resembling Alström syndrome.

Frontiers in genetics·2026
Same journal

Integrative analysis identifies Hspa5 as a key regulator of the ERS/UPR-immune axis in spinal cord injury.

Frontiers in genetics·2026
See all related articles

Related Experiment Video

Updated: Aug 7, 2025

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks
07:50

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks

Published on: November 25, 2015

14.5K

DNA strand displacement based computational systems and their applications.

Congzhou Chen1, Jinda Wen2, Zhibin Wen2

  • 1School of Computer Science, Beijing University of Technology, Beijing, China.

Frontiers in Genetics
|March 13, 2023
PubMed
Summary
This summary is machine-generated.

DNA computing utilizes DNA strand displacement (DSD) for efficient parallel processing and data storage. This review highlights recent DSD system developments and applications in areas like artificial neural networks.

Keywords:
DNA computingDNA strand displacementartificial neural networkscancer detectionintegrated circuits

More Related Videos

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
09:26

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

4.3K
Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography
11:05

Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography

Published on: October 25, 2018

7.6K

Related Experiment Videos

Last Updated: Aug 7, 2025

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks
07:50

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks

Published on: November 25, 2015

14.5K
DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
09:26

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

4.3K
Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography
11:05

Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography

Published on: October 25, 2018

7.6K

Area of Science:

  • Biotechnology
  • Computer Science
  • Molecular Engineering

Background:

  • DNA computing offers superior parallel processing, data storage, and energy efficiency.
  • Computational units are programmed via DNA sequence specificity and base pairing.
  • Cascading and integrating units form complex DNA computing systems.

Purpose of the Study:

  • To review recent advancements in DNA strand displacement (DSD)-based computational systems.
  • To explore the diverse applications of DSD in computing.
  • To discuss DSD-related tools and challenges.

Main Methods:

  • Focus on DNA strand displacement (DSD) as a primary method for system construction.
  • Review of literature on DSD-based logic gates, integrated circuits, and artificial neural networks.
  • Analysis of signal strand transfer for cascading computational units.

Main Results:

  • DSD enables simple yet efficient construction of DNA computing systems.
  • DSD has been successfully applied to create logic gates, integrated circuits, and neural networks.
  • Recent developments show promise for complex computational tasks.

Conclusions:

  • DNA strand displacement is a key technology for advanced DNA computing.
  • Further research into DSD tools and issues will enhance system capabilities.
  • DSD-based systems represent a significant frontier in bio-inspired computing.