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Association of MicroRNA-146a with Type 1 and 2 Diabetes and their Related Complications

Mahyar Ghaffari1, Sara Razi2, Hamidreza Zalpoor3,4

  • 1Department of Biology, Parand Branch, Islamic Azad University, Parand, Iran.

Journal of Diabetes Research
|March 13, 2023
PubMed

Insights

MicroRNA-146a (miR-146a) levels are reduced in type 2 diabetes, impacting disease progression. Restoring miR-146a shows promise in alleviating diabetes complications in preclinical models.

Area of Science:

  • Biochemistry
  • Genetics
  • Endocrinology

Background:

  • Reduced microRNA-146a (miR-146a) blood levels are observed in type 2 diabetes (T2D) patients.
  • miR-146a plays a significant role in the etiology and complications of diabetes mellitus (DM).
  • miR-146a deregulation is implicated in diabetic nephropathy, neuropathy, retinopathy, and cardiovascular disorders.

Purpose of the Study:

  • To comprehensively review the function of miR-146a in diabetes mellitus.
  • To discuss new findings on miR-146a in type 1 (T1DM) and type 2 diabetes (T2DM).
  • To highlight discrepancies between clinical and preclinical investigations of miR-146a in diabetes.

Main Methods:

  • Literature review of existing medical investigations and preclinical studies.
  • Analysis of biological pathways regulated by miR-146a in DM-affected tissues.
  • Comparison of clinical findings with results from animal models.

Main Results:

  • miR-146a mimic injection alleviates diabetes in animal models.
  • miR-146a dysregulation is linked to various diabetic complications.
  • Discrepancies exist between human studies and animal models regarding miR-146a's role.

Conclusions:

  • miR-146a is a critical regulator in diabetes mellitus and its complications.
  • Further research is needed to reconcile clinical and preclinical findings on miR-146a.
  • Targeting miR-146a may offer therapeutic potential for managing diabetes and its sequelae.

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