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Mild Encephalitis/Encephalopathy with a Reversible Lesion in The Splenium

Zerrin Yıldırım1,2, Sibel Mumcu Timer3, Didem Çelik4

  • 1İstanbul University, Aziz Sancar Institute of Experimental Medicine, Department of Neuroscience, İstanbul, Turkey.

Noro Psikiyatri Arsivi
|March 13, 2023
PubMed

Insights

Mild encephalitis/encephalopathy with a reversible lesion in the splenium (MERS) is a brain condition with mild symptoms and reversible splenium lesions. This report details four MERS cases, including one linked to COVID-19.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Radiology

Background:

  • Mild encephalitis/encephalopathy with a reversible lesion in the splenium (MERS) is a clinico-radiological syndrome.
  • It presents with mild central nervous system symptoms and reversible splenium lesions.
  • MERS is often associated with viral and bacterial infections, including COVID-19.

Observation:

  • This paper reports four cases of MERS.
  • The patients presented with diverse underlying conditions.
  • These included mumps infection, aseptic meningitis, Marchiafava-Bignami disease, and atypical pneumonia due to COVID-19.

Findings:

  • The study highlights the varied etiology of MERS.
  • It underscores the association between MERS and different infectious agents.
  • One case demonstrates a link between MERS and Coronavirus disease 2019 (COVID-19).

Implications:

  • Understanding the diverse causes of MERS is crucial for accurate diagnosis.
  • Recognizing MERS in the context of infections like COVID-19 is important for patient management.
  • Further research into the pathogenesis of MERS may reveal new therapeutic targets.
Keywords:
Abducens nerve palsyCOVID-19Marchiafava-Bignami diseaseintracranial hypertensionmild encephalitis/encephalopathy with a reversible splenial lesionmumpspapilledema

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