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Inorganic hollow mesoporous spheres-based delivery for antimicrobial agents
Yunping Qiao1, Yanyang Han1, Rengui Guan1
1Department of Applied Chemistry, School of Chemistry and Chemical Engineering, Yantai University, Clearspring RD 30th, Laishan, Yantai, 264005 China.
Abstract:
Microorganisms coexist with human beings and have formed a complex relationship with us. However, the abnormal spread of pathogens can cause infectious diseases thus demands antibacterial agents. Currently available antimicrobials, such as silver ions, antimicrobial peptides and antibiotics, have diverse concerns in chemical stability, biocompatibility, or triggering drug resistance. The "encapsulate-and-deliver" strategy can protect antimicrobials against decomposing, so to avoid large dose release induced resistance and achieve the controlled release. Considering loading capacity, engineering feasibility, and economic viability, inorganic hollow mesoporous spheres (iHMSs) represent one kind of promising and suitable candidates for real-life antimicrobial applications. Here we reviewed the recent research progress of iHMSs-based antimicrobial delivery. We summarized the synthesis of iHMSs and the drug loading method of various antimicrobials, and discussed the future applications. To prevent and mitigate the spread of an infective disease, multilateral coordination at the national level is required. Moreover, developing effective and practicable antimicrobials is the key to enhancing our capability to eliminate pathogenic microbes. We believe that our conclusion will be beneficial for researches on the antimicrobial delivery in both lab and mass production phases.
Insights
Inorganic hollow mesoporous spheres (iHMSs) offer a promising solution for controlled antimicrobial delivery, overcoming limitations of current agents and preventing drug resistance. This review highlights iHMS synthesis and applications for effective pathogen elimination.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
- Pharmacology
Background:
- Microorganisms interact complexly with humans; pathogen spread necessitates effective antibacterial agents.
- Existing antimicrobials (silver ions, peptides, antibiotics) face challenges like chemical instability, biocompatibility issues, and antimicrobial resistance.
- The "encapsulate-and-deliver" strategy offers controlled release, preventing resistance and decomposition.
Purpose of the Study:
- To review recent advancements in inorganic hollow mesoporous spheres (iHMSs) for antimicrobial delivery.
- To explore the synthesis and drug-loading methods of iHMSs.
- To discuss future applications of iHMS-based antimicrobial systems.
Main Methods:
- Literature review of research progress on iHMS-based antimicrobial delivery.
- Summarization of iHMS synthesis techniques.
- Analysis of various antimicrobial loading methods onto iHMSs.
Main Results:
- Inorganic hollow mesoporous spheres (iHMSs) are identified as promising candidates for antimicrobial delivery due to their loading capacity, engineering feasibility, and economic viability.
- Diverse antimicrobials can be effectively loaded onto iHMSs.
- iHMSs facilitate controlled release, mitigating issues associated with conventional antimicrobials.
Conclusions:
- iHMSs represent a viable strategy for developing effective and practical antimicrobial delivery systems.
- Further research and development in iHMS synthesis and application are crucial for combating infectious diseases.
- This review provides valuable insights for both laboratory research and mass production of antimicrobial delivery systems.
