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Published on: July 17, 2016
Nivolumab-induced acute tubular injury: A case report
Hui-Hsin Yang1, Chia-Wen Chang1, Tai-Di Chen2
1Department of Pharmacy Chang Gung Memorial Hospital, Taoyuan Taoyuan City Taiwan.
Abstract:
Nivolumab belongs to immune checkpoint inhibitors (ICIs). ICIs-induced kidney injury is rare and acute interstitial nephritis (AIN) is the majority. A 58-year-old woman had gastric cancer treated with nivolumab. Her serum creatinine (Cr) increased to 5.94 mg/dL post 2 cycles of nivolumab and co-administered with acemetacin. A kidney biopsy showed acute tubular injury (ATI). Nivolumab rechallenge was done and Cr worsened again. The lymphocyte transformation test (LTT) indicated a strong positive for nivolumab. Although rare, ATI due to ICIs could not be ruled out, and LTT is a tool to identify the culprit.
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