Related Experiment Video
Updated: Aug 7, 2025

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
Dietary factors and risk for asthma: A Mendelian randomization analysis
Wenwen Yang1, Yanjiang Yang2, Li He1
1The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
Fresh fruit and dried fruit intake may reduce asthma risk, while frequent alcohol consumption may increase it. This Mendelian randomization study explored various dietary factors and their link to asthma development.
Area of Science:
- Nutritional Epidemiology
- Genetic Epidemiology
Background:
- Established link between diet and asthma.
- Limited Mendelian randomization studies on diet-asthma relationship.
Purpose of the Study:
- Investigate causal relationships between dietary factors and asthma.
- Utilize Mendelian randomization to assess genetic predisposition.
Main Methods:
- Mendelian randomization analysis using IEU Open GWAS project data.
- Employed weighted median, MR-Egger, and Inverse Variance Weighted methods.
- Performed heterogeneity and pleiotropic analysis for result validation.
Main Results:
- Alcohol intake frequency associated with increased asthma risk (OR: 1.217, p=0.00993).
- Fresh fruit intake (OR: 0.489, p=0.000954) and dried fruit intake (OR: 0.482, p=0.000312) showed protective effects.
- No causal relationship found for other analyzed dietary factors.
Conclusions:
- Dietary patterns, specifically fruit consumption, significantly impact asthma risk.
- Alcohol intake frequency is a risk factor for asthma.
- Further research into specific dietary components and asthma pathogenesis is warranted.
More Related Videos
05:31Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
09:58A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
Published on: April 13, 2010
Related Concept Videos
Asthma-I: Introduction
Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-II: Pathophysiology and Classification
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Antiasthma Drugs: Leukotriene Modifiers
Leukotriene modifiers work through two distinct mechanisms:
Asthma-IV: Diagnostic and Management
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Statistical Methods for Analyzing Epidemiological Data