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The rat MIS1/Pvt-1 locus is syntenic with MYC on chromosome 7
S Ingvarsson1, Z Wirschubsky, J Szpirer
1Department of Tumor Biology, Karolinska Institutet, Stockholm, Sweden.
Cytogenetics and Cell Genetics
|January 1, 1987
Abstract:
Mouse Pvt-1 and rat MIS1 are frequent proviral integration sites in retrovirally induced lymphomas. The Pvt-1 locus is also involved in mouse plasmacytoma (6;15) and in the variant Burkitt lymphoma (2;8) translocations. We show that the Pvt-1/MIS1 locus is syntenic with MYC on rat chromosome 7. This is consistent with a postulate of close linkage and, possibly, a functional relationship between the MYC protooncogene and the MIS1/Pvt-1 locus.