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Cannabidiol-associated hepatotoxicity: A systematic review and meta-analysis
Lindsay A Lo1, April Christiansen2, Lauren Eadie3
1Department of Public Health Sciences, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Journal of Internal Medicine
|March 13, 2023
Summary
Cannabidiol (CBD) use is linked to higher rates of liver enzyme elevation and drug-induced liver injury (DILI). High doses and certain medications increase risk, but severe cases are rare, especially at lower CBD doses.
Area of Science:
- Hepatology
- Pharmacology
- Cannabinoid Science
Background:
- Recent studies indicate potential liver safety concerns with cannabidiol (CBD) use.
- Elevated liver enzymes have been observed in clinical trials involving CBD.
Conclusions:
- Cannabidiol-associated liver enzyme elevations and DILI are considered common adverse drug events.
- Healthcare providers should monitor liver function in patients using CBD, particularly those at higher risk.
- Screening for CBD use is recommended to proactively manage potential hepatotoxicity.

