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Uromodulin: more than a marker for chronic kidney disease progression
Kaice LaFavers1, Pranav S Garimella2
1Division of Nephrology and Hypertension, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
Current Opinion in Nephrology and Hypertension
|March 13, 2023
Summary
Uromodulin, a kidney-produced protein, has evolving roles beyond the urinary tract, impacting systemic health and disease. Research suggests uromodulin
Area of Science:
- Nephrology
- Immunology
- Biochemistry
Background:
- Uromodulin is an evolutionarily conserved protein primarily produced in kidney tubule cells.
- Historically, its function was believed to be confined to the kidney and genitourinary tract.
- Recent research suggests a broader role in systemic human health.
Approach:
- This review synthesizes recent findings on uromodulin's distinct forms and functions.
- It examines the differences between urine uromodulin (uUMOD) and serum uromodulin (sUMOD).
- The review discusses uromodulin's immunomodulatory properties and its role in kidney repair and sepsis.
Key Points:
- Serum uromodulin (sUMOD) differs structurally and functionally from urine uromodulin (uUMOD).
- uUMOD protects against urinary tract infections and aids kidney repair.
- sUMOD may reduce calcification risk, and its upregulation is linked to sepsis survival, while uromodulin knockout mice show increased sepsis mortality.
Conclusions:
- Uromodulin exhibits evolving roles beyond the kidney, influencing systemic homeostasis.
- Further investigation into uromodulin's therapeutic potential is warranted.
- Understanding uromodulin's systemic functions is crucial for human health.
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