Electrophysiological findings in familial exudative vitreoretinopathy

Three patients in a family with familial exudative vitreoretinopathy (FEVR) were studied especially electrophysiologically. Two cases showed abnormal ERG, namely reduction of amplitude of oscillatory potentials, a and b wave of bright white flash ERG, scotopic and photopic b waves. One case showed reduced Light peak/Dark trough ratio of EOG. Next, the electrophysiological findings of cases with FEVR reported in the literature were analyzed. The result was that FEVR has electrophysiological varieties but a statistical significant relationship between electrophysiological findings and visual acuity. That is, cases with abnormal ERG or EOG have more impaired visual acuity than normal ones. Furthermore, there was a tendency that eyes with abnormal ERG or EOG showed more disturbed color vision and advanced fundus findings than normal ones. These results seemed to be understandable by anatomically characteristic fundus feature of FEVR.