Antipyrine metabolism not influenced by level of carbohydrate intake

The effects on antipyrine metabolism of two levels of carbohydrate, fed intravenously as the sole source of nutrition, were compared. After a 36-hour baseline period during which they received 5% dextrose, 440 kcal per day, intravenously, 8 healthy men were administered 2 sequential intravenous nutritional regimens for 3 days each. One regimen consisted of dextrose 8.1 kcal per kg per day and the other 30.7 kcal per kg per day. The order of the 2 regimens was randomized. Antipyrine metabolism was studied on the last day of each nutritional regimen. Antipyrine kinetics were not influenced by level of carbohydrate intake. Our study indicates that in humans carbohydrate does not by itself have an effect on oxidative drug-metabolizing capacity.