Urea- and Thiourea-Based Receptors for Anion Binding.
Sanchita Kundu1, Tochukwu Kevin Egboluche1, Md Alamgir Hossain1
1Department of Chemistry and Biochemistry, Jackson State University, 1400 J. R. Lynch Street, Jackson, Mississippi 39217, United States.
Accounts of Chemical Research
|March 13, 2023
Summary
Synthetic receptors like urea and thiourea derivatives show promise for anion recognition through hydrogen bonding. Their design, including linkers and functionalities, influences binding strength and selectivity for applications in chemistry and biology.
Area of Science:
- Supramolecular Chemistry
- Synthetic Receptors
- Anion Recognition
Background:
- Anions play crucial roles in chemical, environmental, and biological processes.
- Urea- and thiourea-based molecules are effective synthetic receptors for anions via hydrogen bonding.
- Thiourea receptors offer enhanced anion binding due to the increased acidity of thiocarbonyl groups.
Purpose of the Study:
- To summarize efforts in exploring urea- and thiourea-based synthetic receptors for anion coordination chemistry.
- To investigate the influence of linker type, receptor dimension, and functionalization on anion binding.
- To highlight the development of receptors for anion binding, sensing, and separation.
Main Methods:
- Experimental and computational studies of synthetic receptors with varying structures.
- Analysis of anion binding modes (1:1, 1:2) based on receptor architecture (dipodal, tripodal, hexafunctional).
- Incorporation of chromophores for naked-eye anion detection.
Main Results:
- Dipodal receptors with flexible or rigid linkers form clefts for anion binding.
- Tripodal receptors create organized cavities, predominantly forming 1:1 complexes.
- Hexafunctional receptors can bind multiple anions, with binding sites influenced by linker type.
- Receptors with terminal chromophores enable visual detection of specific anions like fluoride and acetate.
Conclusions:
- Receptor design, including linkers and functional groups, significantly impacts anion binding strength and selectivity.
- Synthetic receptors offer tunable platforms for selective anion recognition.
- These findings contribute to the development of novel devices for anion management in various applications.
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