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Updated: Aug 4, 2026

Comprehensive Assessment of Germline Chemical Toxicity Using the Nematode Caenorhabditis elegans
Published on: February 22, 2015
Comparative results of 327 chemical carcinogenicity studies
J K Haseman1, J E Huff, E Zeiger
1National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
Abstract:
The National Cancer Institute (NCI) and the National Toxicology Program (NTP) have carried out a number of laboratory animal carcinogenicity studies and presented the results of these experiments in a series of Technical Reports. This paper tabulates the results of the 327 NCI/NTP studies carried out to date on 308 distinct chemicals, and discusses certain issues relevant to the evaluation of carcinogenicity in these experiments. This compilation of results from NCI/NTP carcinogenicity experiments provides a large database that can be used to study structure-activity correlations, interspecies concordance, and associations between laboratory animal carcinogenicity and other toxicological effects.
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