Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cystic Fibrosis: Pathogenesis

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...

Cystic Fibrosis: Management

Cystic Fibrosis: Management

Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...

Respiratory System Abnormal Finding I: Inspection and Percussion

Respiratory System Abnormal Finding I: Inspection and Percussion

Respiratory system abnormalities are a significant concern in healthcare due to their potential to indicate underlying severe conditions like Chronic Obstructive Pulmonary Disease (COPD), asthma, and pneumonia. These abnormalities can often be detected through physical examination methods like inspection and percussion.
Inspection Findings
During an inspection, several findings may suggest the presence of respiratory distress or disease. Pursed-lip breathing, where exhalation is slowed by...

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History

Respiratory System Abnormal Finding II: Palpation and Auscultation

Respiratory System Abnormal Finding II: Palpation and Auscultation

In assessing respiratory abnormalities, palpation and auscultation are critical tools for detecting and interpreting various pathophysiological changes. These techniques provide insight into underlying disorders by evaluating tactile sensations and sounds produced by the respiratory system.
Palpation Findings
During a respiratory assessment, palpation can reveal several vital abnormalities:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Does Inhaled Marijuana Use Have an Adverse Effect On Asthma?: An Incomplete Answer.

Chest·2026

Same author

Ebola laboratory preparedness at frontline hospitals: can we or can't we?

Journal of clinical microbiology·2026

Same author

Correspondence: A two-step algorithm for pharmacologic management of COPD: Bridging foundational and personalized medicine.

Respiratory medicine·2026

Same author

Lack of methodological clarity in the report of the association of cannabis use and lung cancer.

Lung cancer (Amsterdam, Netherlands)·2026

Same author

Non-invasive respiratory support attenuates lung damage in a murine model of bronchopulmonary dysplasia.

Frontiers in pediatrics·2026

Same author

Antimicrobial nanomaterials at the nanoscale: design principles, mechanisms, and global challenges.

Nanoscale advances·2026

Search research articles

Related Experiment Video

Updated: Aug 7, 2025

Forskolin-induced Swelling in Intestinal Organoids: An In Vitro Assay for Assessing Drug Response in Cystic Fibrosis Patients

Forskolin-induced Swelling in Intestinal Organoids: An In Vitro Assay for Assessing Drug Response in Cystic Fibrosis Patients

Published on: February 11, 2017

Isolated abnormal FEF75% detects unsuspected bronchiolar obstruction in CF children.

Vicki K Masson^1,2,3, Eliezer Nussbaum¹, Arthur F Gelb^4,5,6

¹Pulmonary Division, Miller Children's and Women's Hospital, Long Beach Memorial Hospital, Long Beach, CA, USA.

Pediatric Research

|March 14, 2023

Summary

Early detection of small airways obstruction in children with cystic fibrosis (CF) is possible using FEF75% spirometry, even with normal routine tests. This finding aids in optimizing therapies for CF patients with suspected lung disease.

More Related Videos

Rectal Organoid Morphology Analysis ROMA: A Diagnostic Assay in Cystic Fibrosis

Rectal Organoid Morphology Analysis ROMA: A Diagnostic Assay in Cystic Fibrosis

Published on: June 10, 2022

Generation of Human Nasal Epithelial Cell Spheroids for Individualized Cystic Fibrosis Transmembrane Conductance Regulator Study

Generation of Human Nasal Epithelial Cell Spheroids for Individualized Cystic Fibrosis Transmembrane Conductance Regulator Study

Published on: April 11, 2018

Related Experiment Videos

Last Updated: Aug 7, 2025

Forskolin-induced Swelling in Intestinal Organoids: An In Vitro Assay for Assessing Drug Response in Cystic Fibrosis Patients

Forskolin-induced Swelling in Intestinal Organoids: An In Vitro Assay for Assessing Drug Response in Cystic Fibrosis Patients

Published on: February 11, 2017

Rectal Organoid Morphology Analysis ROMA: A Diagnostic Assay in Cystic Fibrosis

Rectal Organoid Morphology Analysis ROMA: A Diagnostic Assay in Cystic Fibrosis

Published on: June 10, 2022

Generation of Human Nasal Epithelial Cell Spheroids for Individualized Cystic Fibrosis Transmembrane Conductance Regulator Study

Generation of Human Nasal Epithelial Cell Spheroids for Individualized Cystic Fibrosis Transmembrane Conductance Regulator Study

Published on: April 11, 2018

Area of Science:

Pediatric Pulmonology
Respiratory Medicine
Cystic Fibrosis Research

Background:

Physiologic detection of bronchiolar obstruction in children with cystic fibrosis (CF) can be challenging due to normal spirometry despite CT-confirmed bronchiectasis.
Small airways obstruction in CF may go clinically unsuspected.

Purpose of the Study:

To investigate the utility of specific spirometric measures, particularly FEF75%, in detecting early and isolated small airways obstruction in children with CF.
To assess if FEF75% can identify subclinical airway disease in CF patients with normal routine spirometry.

Main Methods:

Retrospective analysis of spirometry data from children at two CF facilities over 16 years.
Focus on pre-bronchodilator maximum expiratory flow volume curves to identify abnormal FEF75% despite normal routine spirometry.
Data collected every 3 months during clinically stable periods.

Main Results:

An abnormal FEF75% was detected in 26 CF children at a mean age of 7.5 years, persisting as an isolated abnormality for 2.5 years.
At another center, abnormal FEF75% occurred in 13 children (mean age 11.7 years), and abnormal FEF25-75% in 10 (mean age 11.8 years), despite initially normal spirometry.
FEF75% proved to be the most sensitive test for diagnosing early and isolated progressive bronchiolar obstruction.

Conclusions:

FEF75% is a sensitive spirometric marker for detecting unsuspected small airways obstruction in children with CF.
This test can identify subclinical disease in CF patients with normal routine spirometry and bronchiectasis, allowing for optimized targeted therapies.