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Related Concept Videos

Colloids03:22

Colloids

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Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles that are visible to the naked eye or can be seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. On the other hand, a solution is a homogeneous mixture in which no settling occurs and in which the dissolved...
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The plasma membrane, a critical structure in cellular biology, houses an array of transporters, or carrier proteins, interspersed within its lipid bilayer. These proteins play a crucial role in solute transport through facilitated diffusion, a form of passive diffusion that uses transporters to move the molecules across the membrane.
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Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange.
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Pore Transport and Ion-Pair Transport01:17

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Pore transport and ion-pair formation are critical mechanisms for the absorption and distribution of drugs in the body.
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The Significance of Membrane Transport

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The transport of solutes across the cell membrane is essential for metabolic processes, like maintaining cell size and volume, generating the action potential, exchanging nutrients and gases, etc. Membrane transport can be either passive or active. It can be simple diffusion, facilitated, or mediated transport aided by transport proteins such as transporters and channels.
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Transcellular transport of solutes is the movement of substances like monosaccharides and amino acids through polarized cells. This transport mechanism is primarily seen in epithelial and endothelial cells aided by membrane transport proteins such as channels and transporters. The tight junctions between these cells confine the membrane proteins to the two sides of the cell. The epithelial cells have distinct apical and basolateral domains. In contrast, the endothelial cells show the luminal...
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Preparation and Friction Force Microscopy Measurements of Immiscible, Opposing Polymer Brushes
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Selective Colloid Transport across Planar Polymer Brushes.

Mikhail Y Laktionov1, Ekaterina B Zhulina2, Leonid Klushin2,3

  • 1ITMO University, 49 Kronverksky Prospekt, Saint Petersburg, 197101, Russia.

Macromolecular Rapid Communications
|March 14, 2023
PubMed
Summary
This summary is machine-generated.

This study presents a theory for colloid transport in polymer brushes, showing how to tune surface coatings for selective binding and movement. This enables the design of advanced sensing and purification devices.

Keywords:
colloidsdiffusionmacromolecular interactionspolymer brushesselective transport

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Area of Science:

  • Surface science
  • Colloid science
  • Polymer physics

Background:

  • Polymer brushes are versatile surface coatings with biological and technological relevance.
  • Understanding colloid interaction with polymer brushes is crucial for applications but remains under-studied.

Purpose of the Study:

  • To develop a theoretical framework for analyzing colloid binding and transport in planar polymer brushes.
  • To investigate the influence of solvent strength and colloid-polymer affinity on these processes.

Main Methods:

  • A mean-field theoretical approach was employed.
  • The theory explicitly considers solvent effects on brush conformation.
  • Colloid-polymer affinity's impact on binding and transport was analyzed.

Main Results:

  • A position-dependent free energy for colloid insertion was derived, governing transport rates.
  • The study demonstrates tuneable selectivity of polymer brushes for colloids based on size and affinity.
  • Optimal conditions for high brush permeability and selectivity were identified.

Conclusions:

  • The developed theory provides a method to design polymer brushes as selective gates for colloids.
  • This work can advance the development of sensing and purification devices.
  • It also enhances understanding of biological polymer brush functions.