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Related Experiment Video

Updated: Aug 7, 2025

Plasmonic Photothermal Cancer Therapy: Nanoparticle-embedded Tumor-tissue-mimicking Phantoms for Visualizing Photothermal Temperature Distribution

Plasmonic Photothermal Cancer Therapy: Nanoparticle-embedded Tumor-tissue-mimicking Phantoms for Visualizing Photothermal Temperature Distribution

Published on: May 9, 2025

Solid optical tissue phantom tools based on upconverting nanoparticles for biomedical applications.

Gokhan Dumlupinar^1,2, Sanathana Konugolu Venkata Sekar^1,3, Claudia Nunzia Guadagno³

¹Tyndall National Institute, Biophotonics@Tyndall, IPIC, Cork, Ireland.

Journal of Biomedical Optics

|March 14, 2023

Summary

This summary is machine-generated.

This study introduces a novel manufacturing recipe and tools for upconverting nanoparticle (UCNP) phantoms, crucial for advancing UCNP biophotonics applications. These UCNP phantoms demonstrate stability and linear response, accelerating biophotonics research.

Keywords:

biophotonics phantoms photon time-of-flight spectroscopy standards upconverting nanoparticles

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Published on: August 22, 2018

Area of Science:

Biophotonics
Nanotechnology
Materials Science

Background:

Phantoms are essential for developing biophotonics techniques.
A gap exists in novel phantom tools for upconverting nanoparticles (UCNPs) in biophotonics.

Purpose of the Study:

To provide a well-characterized UCNP-based solid phantom recipe and tools.
To support a wide range of UCNP-based biophotonics applications.

Main Methods:

Developed a silicone-matrix-based solid phantom recipe for UCNPs.
Utilized a custom UCNP imaging system for characterization (linearity, homogeneity, stability).
Employed photon time-of-flight spectroscopy for optical property assessment.

Main Results:

Manufactured 24 phantoms in four types: homogeneous, multilayer, inclusion, and base.
Demonstrated linear response of UCNP phantoms across a dosage range.
Confirmed phantom stability over 4 months (CV ) and observed reduced UCNP emission with increased tissue depth.

Conclusions:

Presented a novel UCNP-based solid phantom recipe and four types of phantom tools.
UCNP phantoms showed dosage linearity and temporal stability.
The developed phantoms are poised to significantly advance UCNP biophotonics research and applications.