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Polypharmacy Pattern in Iran: A Comprehensive Analysis of a Large Prescription Database
Reza Ebrahimoghli1, Ali Janati2, Hojatolah Gharaee3
1Department of Nursing, Institute of Health Education, Ardabil University of Medical Sciences, Ardabil, Iran.
Iranian Journal of Pharmaceutical Research : IJPR
|March 14, 2023
Summary
Polypharmacy affects over a quarter of outpatients, with continuous use common. Female sex, older age, and chronic conditions increase polypharmacy risk.
Area of Science:
- Pharmacology
- Public Health
- Geriatrics
Background:
- Polypharmacy, the concurrent use of multiple medications, presents a significant patient safety challenge.
- Understanding its prevalence and contributing factors is crucial for effective healthcare management.
Purpose of the Study:
- To determine the prevalence and continuity of polypharmacy in East Azerbaijan province, Iran.
- To identify associated factors and common medication classes among outpatients.
Main Methods:
- Retrospective analysis of prescription data for over 300,000 outpatients aged 20+.
- Polypharmacy defined as >4 medications concurrently; continuous polypharmacy over two periods.
- Multivariate logistic regression used to identify risk factors.
Main Results:
- Polypharmacy observed in 28.3% of patients; 36.6% experienced continuous polypharmacy.
- Increased odds of polypharmacy associated with female sex, older age, and chronic conditions.
- Commonly used medication classes included those for GERD, beta-blockers, antidepressants, glucose-lowering drugs, and antithrombotics.
Conclusions:
- Findings highlight the substantial burden of polypharmacy in this population.
- Strategies are needed to inform policymakers and providers about polypharmacy's scope and associated risks.
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