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Quality improvement study on the effectiveness of intranasal povidone-iodine decolonization on surgery patients

Eric N Hammond1,2, Ashley E Kates2,3, Nathan Putman-Buehler4

  • 1Institute for Clinical and Translational Research, University of Wisconsin-Madison, Madison, WI, 53705, USA.

Infection Prevention in Practice
|March 14, 2023
PubMed
Abstract

Insights

Preoperative intranasal povidone-iodine effectively reduced Staphylococcus aureus nasal carriage in surgical patients. This quality improvement study demonstrates its potential for surgical site infection prevention.

Area of Science:

  • Infectious Disease
  • Surgical Safety
  • Microbiology

Background:

  • Surgical site infections (SSIs) pose a global healthcare challenge.
  • Intranasal mupirocin use for decolonization has limitations.
  • Preoperative intranasal povidone-iodine is an alternative decolonization strategy.

Purpose of the Study:

  • To evaluate the efficacy of a single preoperative intranasal povidone-iodine application.
  • To assess the reduction in Staphylococcus aureus nasal carriage post-surgery.

Main Methods:

  • Quality improvement study involving ambulatory surgery patients.
  • Pre- and post-operative nasal samples collected for S. aureus analysis.
  • Samples analyzed using PCR and qualitative culturing.

Main Results:

  • 36% of patients showed S. aureus nasal colonization pre-surgery via PCR.
  • 28% tested positive for S. aureus pre-surgery via culture.
  • 20% tested positive for S. aureus post-surgery via culture (P=0.039).

Conclusions:

  • A single preoperative intranasal povidone-iodine application effectively decolonizes S. aureus from the nares.
  • Proper implementation is key to its success in reducing nasal carriage.
Keywords:
EffectivenessIntranasal povidone-iodineMethicillin-resistant Staphylococcus aureusMethicillin-susceptible Staphylococcus aureusPreoperative intranasal decolonizationStaphylococcus aureus

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