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Updated: Aug 7, 2025
A Traditional Chinese Medicine Characteristic Therapy for Bronchial Asthma: Moxibustion
Published on: May 12, 2023
Therapeutic effect of modified Xiaoqinglong Decoction on cough-variant asthma and immunological functioning in
1Department of Integrated Traditional Chinese and Western Medicine, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology Wuhan 430010, Hubei, China.
Objective:
To investigate the effect of modified Xiaoqinglong Decoction on cough variant asthma (CVA) and immunological functioning in children.
Methods:
In this is retrospective analysis, 122 children with CAV admitted to our hospital from Mar. 2021 to Mar. 2022 were divided into an observation group (n=61) and a control group (n=61) according to treatment methods. The control group received fluticasone propionate inhalation aerosol, and the observation group additionally received Xiaoqinglong Decoction. The therapeutic efficacy in the two groups was compared after 8 weeks of treatment. The comparison indictors included scores of daytime and nighttime cough, pulmonary function, fractional exhaled nitric oxide (FeNO), eosinophil count, inflammatory response (interleukin-4 (IL-4), tumor necrosis factor-α (TNF-α) and macrophage inflammatory protein ((MIP)-1α), immunoglobulin (Ig)) level and adverse reactions.
Results:
The overall response rate of children with CVA in the observation group was higher than that in the control group (P<0.05). After treatment, the scores of daytime and nighttime cough in the observation group were lower than those in the control group (P<0.05). The Forced Vital Capacity (FVC), peak expiratory flow (PEF) and FEV1 (Forced Expiratory Volume)/FVC of the observation group were higher than those in the control group (P<0.05). The FeNO and eosinophil count in the observation group were lower than those in the control group (P<0.05). The serum IL-4 was higher, while TNF-α and MIP-1α levels were lower in the observation group in the control group (P<0.05). The serum IgA, IgG and IgM levels in the observation group were higher than those in the control group (P<0.05).
Conclusion:
The modified Xiaoqinglong Decoction has a conspicuous effect on children with CVA. It helps to reduce cough symptoms, improve pulmonary function, reduce inflammatory response and improve immunological functioning of children.
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