Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A review of the impact of structural racism on lived experiences of adolescents of African descent: Implications for development, brain structure, and health.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2025
Same author

Persistent Neutropenia and Atopy in an Adolescent: A Subtle Presentation of Phosphoglucomutase 3 Deficiency.

Cureus·2025
Same author

Association Between Natural Lithium Exposure and Suicide Rate: An Ecological and Biomonitoring Study in Portugal.

Nutrients·2025
Same author

Intersectional Dynamics of Race, Ethnicity, and Immigration: Examining Health Outcomes among Black Immigrant Youth through Ethnic-Racial Identity Development and Critical Consciousness.

Human development·2025
Same author

Newborn Screening for Sickle Cell Disease: Results from a Pilot Study in the Portuguese Population.

International journal of neonatal screening·2025
Same author

Coronary septic embolism presenting as acute myocardial infarction. A case report of a singular manifestation of infective endocarditis.

European heart journal. Case reports·2025
Same journal

Complete Genome Sequence of <i>Rhodococcus equi</i> Phage Nova53.

microPublication biology·2026
Same journal

Modeling Inherited Methylmalonic Acidemia Using Isogenic Human Induced Pluripotent Stem Cell-Derived Hepatocytes with Mutations in <i>Methylmalonyl-CoA Mutase</i>.

microPublication biology·2026
Same journal

Invasive African fig flies ( <i>Zaprionus indianus</i> ) have reduced cold acclimation ability compared to cosmopolitan drosophilid species.

microPublication biology·2026
Same journal

An activating mutation in AGEF-1, a putative Arf GEF, causes yolk extrusion from <i>C. elegans</i> embryos.

microPublication biology·2026
Same journal

Diel Activity Patterns of Bobcats and Domestic Cats in the Houston Metropolitan Area.

microPublication biology·2026
Same journal

Exploring the Effects of Antioxidants on αSynuclein-Induced Motor Deficits in <i>Drosophila</i> Larvae.

microPublication biology·2026
See all related articles

Related Experiment Video

Updated: Aug 7, 2025

Isolation and Culture of Adult Zebrafish Brain-derived Neurospheres
11:01

Isolation and Culture of Adult Zebrafish Brain-derived Neurospheres

Published on: February 29, 2016

13.0K

Mob4 is required for neurodevelopment in zebrafish.

Claudia Florindo1,2,3, Jorge M Mimoso1,4, Sandra L Palma1,5

  • 1Faculty of Medicine and Biomedical Sciences. University of Algarve.

Micropublication Biology
|March 14, 2023
PubMed
Summary
This summary is machine-generated.

Mob4 protein is crucial for limiting neuronal cell divisions during zebrafish development. This study reveals Mob4

More Related Videos

An Assay for Permeability of the Zebrafish Embryonic Neuroepithelium
06:37

An Assay for Permeability of the Zebrafish Embryonic Neuroepithelium

Published on: October 24, 2012

9.6K
Behavioral Approaches to Studying Innate Stress in Zebrafish
05:29

Behavioral Approaches to Studying Innate Stress in Zebrafish

Published on: May 1, 2019

9.1K

Related Experiment Videos

Last Updated: Aug 7, 2025

Isolation and Culture of Adult Zebrafish Brain-derived Neurospheres
11:01

Isolation and Culture of Adult Zebrafish Brain-derived Neurospheres

Published on: February 29, 2016

13.0K
An Assay for Permeability of the Zebrafish Embryonic Neuroepithelium
06:37

An Assay for Permeability of the Zebrafish Embryonic Neuroepithelium

Published on: October 24, 2012

9.6K
Behavioral Approaches to Studying Innate Stress in Zebrafish
05:29

Behavioral Approaches to Studying Innate Stress in Zebrafish

Published on: May 1, 2019

9.1K

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Neuroscience

Background:

  • Mob4 is an evolutionarily conserved protein and a key component of the STRIPAK complex.
  • While Mob4's role in Drosophila is known, its function in vertebrate development is largely unexplored.
  • The STRIPAK complex is involved in critical cellular processes including cell division and signaling.

Purpose of the Study:

  • To investigate the function of Mob4 in vertebrate development, specifically in zebrafish embryos.
  • To determine Mob4's role in neurodevelopment and cell division during embryogenesis.

Main Methods:

  • Knockdown and knockout of Mob4 gene in zebrafish embryos.
  • Analysis of neuronal cell divisions and apoptosis during zebrafish embryogenesis.

Main Results:

  • Zebrafish embryos with Mob4 knockdown or knockout exhibited limited neuronal cell divisions.
  • Eliminating Mob4 function had minimal impact on apoptosis in developing zebrafish.
  • These findings suggest a specific role for Mob4 in regulating neurodevelopment.

Conclusions:

  • Mob4 plays a significant role in regulating neuronal cell division during zebrafish embryogenesis.
  • The protein is essential for normal neurodevelopment in vertebrates.
  • Further research is warranted to fully elucidate Mob4's mechanisms within the STRIPAK complex and its broader developmental functions.