Serum TSH Levels are Associated with Hyperactivity Behaviors in Children with Attention Deficit/Hyperactivity
Guanru Chen1, Wenfan Gao2,3,4, Yayun Xu5
1Department of Clinical Pharmacy, Anhui Provincial Children's Hospital, Hefei, Anhui, People's Republic of China.
Insights
Thyroid stimulating hormone (TSH) levels correlate with hyperactivity in children with attention deficit/hyperactivity disorder (ADHD). Elevated TSH may indicate hyperactivity in ADHD patients.
Area of Science:
- Endocrinology
- Neuroscience
- Pediatrics
Background:
- Maternal thyroid dysfunction is linked to increased ADHD risk in offspring.
- The specific relationship between thyroid function and ADHD symptoms in children requires further clarification.
Purpose of the Study:
- To investigate the correlation between thyroid hormone levels and ADHD symptom severity.
- To identify factors associated with hyperactivity in children diagnosed with ADHD.
Main Methods:
- Assessed 49 children with ADHD using the Conners 3 scale for symptom evaluation.
- Employed Pearson correlation, univariate analysis, binary logistic regression, and ROC curve analysis.
- Compared thyroid hormones and other parameters between ADHD children with and without hyperactivity behaviors.
Main Results:
- Thyroid stimulating hormone (TSH) levels positively correlated with ADHD symptom scores and hyperactivity index.
- Children with hyperactivity exhibited significantly higher TSH, serum ferritin, and lactic acid levels.
- TSH and lactic acid were independently associated with hyperactivity, with TSH showing potential diagnostic value.
Conclusions:
- Serum TSH levels appear to be associated with hyperactivity in children with ADHD.
- TSH may serve as a potential biomarker for identifying hyperactivity in ADHD patients.
Objective:
Previous studies indicated that maternal thyroid dysfunction increase the offspring's risk for attention deficit/hyperactivity disorder (ADHD). However, the relationship between thyroid function and symptoms in children with ADHD remains unclear.
Methods:
A total of 49 children with ADHD were enrolled. The Conners 3 scale was used to estimate the symptoms associated with ADHD. Correlation between thyroid hormones and the scores of the Conners 3 scale was evaluated by Pearson correlation analysis. Then, ADHD children were divided into two groups according to the hyperactivity index (HI) of the Conners 3 scale: ADHD children with hyperactivity behaviors (HB) (HI > 1.5) and ADHD children without HB (HI < 1.5). The demographic characteristics, thyroid hormones, and routine laboratory parameters between the two groups were collected. To distinguish HI-related factors, a univariate analysis and a binary logistic regression predictive model were used. The discriminative ability of thyroid stimulating hormone (TSH) in predicting ADHD children with HB from ADHD children without HB was investigated using the receiver operating characteristic (ROC) curve method.
Results:
The levels of TSH were positively correlated to the scores of the Conners 3 scale (r = 0.338, P = 0.033) and HI (r = 0.371, P = 0.019). Moreover, the levels of TSH, serum ferritin, and lactic acid were significantly increased in ADHD children with HB compared to ADHD children without HB (all P < 0.05). Furthermore, the results of binary logistic regression found that TSH (OR 2.243 (CL 1.052-4.783)) and lactic acid (OR 1.018 (CI 1.003-1.032)) were independently associated with HI. Additionally, ROC analysis indicated the potential diagnostic value of TSH in discriminating ADHD children with HB from ADHD children without HB with an AUC of 0.684.
Conclusion:
These results suggested that the serum TSH levels may be related to the HB in children with ADHD.
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