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Research progress of fibroblast growth factor in nervous system diseases

Wenting Huang1, Wanhua Qiu2, Kun Chen2

  • 11. Department of Neurology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.

Zhejiang Da Xue Xue Bao. Yi Xue Ban = Journal of Zhejiang University. Medical Sciences
|March 14, 2023
PubMed

Insights

Fibroblast growth factors (FGFs) are crucial for central nervous system (CNS) injury repair. This review details FGF signaling

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Cell Signaling

Background:

  • Fibroblast growth factors (FGFs) comprise a family of signaling molecules involved in cellular communication.
  • The FGF signaling pathway is increasingly recognized for its role in central nervous system (CNS) repair processes.

Purpose of the Study:

  • To comprehensively review the latest research on FGF signaling in the context of CNS injury and diseases.
  • To explore the therapeutic potential of FGFs for neurological disorders.

Main Methods:

  • Literature review of studies on FGF signaling pathways.
  • Analysis of FGF's role in various CNS injury models and neurodegenerative diseases.
  • Synthesis of current understanding of FGF-mediated protective mechanisms.

Main Results:

  • FGF signaling activates protective pathways like PI3K-Akt and PPARγ.
  • FGFs inhibit detrimental processes including inflammation (NF-κB), oxidative stress, and apoptosis.
  • FGFs modulate neuronal differentiation, excitability, and neurovascular unit protection.

Conclusions:

  • FGF signaling pathways offer significant therapeutic targets for CNS injury and neurological diseases.
  • Understanding FGF mechanisms provides a basis for developing novel FGF-based drugs for conditions like stroke, TBI, Alzheimer's, and Parkinson's.
Keywords:
Alzheimer’s diseaseCerebral hemorrhageCerebral infarctionDepressive disorderEpilepsyFibroblast growth factorParkinson’s diseaseReviewTraumatic brain injury

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