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Related Experiment Videos

Benzodiazepine Ro 5-4864 increases coronary flow.

I L Grupp1, J F French, M A Matlib

  • 1Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, OH 45267-0575.

European Journal of Pharmacology
|November 3, 1987
PubMed
Summary

Certain benzodiazepines, like Ro 5-4864 (chlorodiazepam), specifically increase coronary blood flow in rat hearts without impacting heart rate or contractility. The exact mechanism behind this vasodilatory effect remains undetermined.

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Area of Science:

  • Pharmacology
  • Cardiovascular Physiology
  • Neuroscience

Background:

  • Benzodiazepines are known for their central nervous system effects.
  • Some benzodiazepines may have peripheral actions.
  • Ro 5-4864 (chlorodiazepam) is a specific benzodiazepine with poorly understood cardiovascular effects.

Purpose of the Study:

  • To investigate the specific cardiovascular effects of Ro 5-4864 (chlorodiazepam) on coronary blood flow.
  • To compare the effects of Ro 5-4864 with another benzodiazepine, Ro 5-4023 (clonazepam).
  • To explore the role of the benzodiazepine binding site in cardiac muscle using PK 11195.

Main Methods:

  • Isolated retrograde perfused Langendorff rat heart preparations were used.
  • Coronary flow, heart rate, and left ventricular contractility (dP/dt) were measured.

Related Experiment Videos

  • The effects of Ro 5-4864, Ro 5-4023, and PK 11195 were assessed.

    • Main Results:

    • Ro 5-4864 significantly increased coronary flow.
    • Ro 5-4864 did not alter heart rate or left ventricular contractility.
    • Ro 5-4023 showed minimal effects on coronary flow.
    • PK 11195, an inhibitor of Ro 5-4864 binding, did not block the vasodilatory effect and increased coronary flow independently.

    Conclusions:

    • Certain benzodiazepines, specifically Ro 5-4864, possess a specific vasodilatory effect on the coronary vasculature.
    • This effect is independent of changes in heart rate or contractility.
    • The mechanism of action for this benzodiazepine-induced vasodilation is currently unknown and warrants further investigation.