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Updated: Aug 7, 2025

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
11:12

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies

Published on: September 13, 2024

461

Metabolomics meets systems immunology.

Jianbo Fu1,2,3, Feng Zhu3, Cheng-Jian Xu1,2,4

  • 1Centre for Individualised Infection Medicine (CiiM), a joint venture between the Helmholtz Centre for Infection Research (HZI) and Hannover Medical School (MHH), Hannover, Germany.

EMBO Reports
|March 14, 2023
PubMed
Summary
This summary is machine-generated.

Metabolomics, the study of small molecules, offers new ways to understand how metabolism impacts immune regulation. This review guides researchers in applying metabolomics and multiomics for advanced systems immunology and disease research.

Keywords:
infectionmetabolomicsmultiomicsstatistical analysissystems immunology

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Area of Science:

  • Immunology
  • Metabolomics
  • Systems Biology

Background:

  • Metabolic processes are crucial for immune system regulation.
  • Metabolomics provides a comprehensive approach to study metabolism-immunity interactions in health and disease.
  • Integrating metabolomics into systems immunology reveals complex biological interactions and regulatory mechanisms.

Purpose of the Study:

  • To provide an overview of recent technological advancements in metabolomic applications for immunology research.
  • To compare targeted and untargeted metabolomics approaches.
  • To guide researchers on integrating metabolomics with other omics for systems immunology.

Main Methods:

  • Comparison of targeted and untargeted metabolomics.
  • Overview of the metabolomics analysis workflow: sample preparation, data preprocessing, processing, statistical analysis, and interpretation.
  • Discussion of computational tools for metabolomics and multiomics integration.

Main Results:

  • Recent technological developments enhance metabolomic applications in immunology.
  • Established workflows and computational tools facilitate metabolomics data analysis and integration.
  • Multiomics integration offers deeper insights into immunological processes.

Conclusions:

  • Metabolomics is a powerful tool for understanding immune regulation and disease.
  • Integration of metabolomics with other omics approaches advances systems immunology.
  • This review serves as a guide for researchers utilizing metabolomics and multiomics in immunity research.