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Updated: Aug 7, 2025
28:13
Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
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Real-World Evaluation of Anticoagulant Treatment Patterns in Patients with Atrial Fibrillation: Data from Multicenter
Umut Kocabaş1, Işıl Ergin2, Veysel Yavuz3
1Başkent University Izmir Hospital, Department of Cardiology, Izmir, Türkiye.
Summary
The ROTA study reveals suboptimal anticoagulant use in atrial fibrillation patients. Many received incorrect dosages or had poor therapeutic range, increasing stroke risk despite available treatments.
Area of Science:
- Cardiology
- Pharmacology
- Real-world evidence
Background:
- Oral anticoagulant therapy is crucial for preventing stroke in atrial fibrillation.
- Limited real-world data exists on current anticoagulant treatment patterns and effectiveness.
Purpose of the Study:
- To gather real-world data on anticoagulant treatment patterns in atrial fibrillation patients.
- To assess the utilization and effectiveness of anticoagulants in a large patient cohort.
Main Methods:
- Prospective, multicenter, observational study.
- Included 2597 patients with atrial fibrillation from cardiology outpatient clinics.
- Data collected between January 2021 and May 2021.
Main Results:
- Vitamin K antagonists (VKAs) used in 15.9%, direct oral anticoagulants (DOACs) in 79.4%.
- 76% of VKA patients had inadequate time in therapeutic range (<70%).
- High overuse (76.1%) in low-risk patients; over 25% of DOAC patients received reduced doses.
Conclusions:
- The ROTA study highlights significant real-world challenges in anticoagulant management for atrial fibrillation.
- Suboptimal treatment patterns, including incorrect dosing and poor therapeutic range, were prevalent.
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