How to Critically Appraise and Interpret Systematic Reviews and Meta-Analyses of Diagnostic Accuracy: A User Guide

Robert A Frank¹, Jean-Paul Salameh¹, Nayaar Islam¹+13

• ¹From the Department of Radiology, University of Ottawa, The Ottawa Hospital Civic Campus, 1053 Carling Ave, Room c159, Ottawa, ON, Canada K1Y 4E9 (R.A.F., M.D.F.M.); Faculty of Health Sciences, Queen's University, Kingston, Ontario, Canada (J.P.S.); Clinical Epidemiology Program, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada (N.I., M.H.M., H.D., S.E., B.H.); Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (B.Y.); Evidence-Based Practice Center, Mayo Clinic, Rochester, Minn (M.H.M.); Department of Medicine, Division of Nephrology and Hypertension, University of Kansas Medical Center, Kansas City, Mo (R.M.); Department of Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands (M.L., P.M.B.); Amsterdam Public Health, Amsterdam, the Netherlands (P.M.B.); Institute of Applied Health Research, University of Birmingham, Birmingham, UK (Y.T.); NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Birmingham, UK (Y.T.); Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK (P.W.); Department of Radiology, NYU Langone Health, New York, NY (S.K.K.); and Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Canada (B.L.).