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Related Concept Videos

Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

1.7K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.7K
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

19
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
19
Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

23
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
23
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

29
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
29
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

18
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
18
Heart Failure VII: Nursing Interventions01:30

Heart Failure VII: Nursing Interventions

129
The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...
129

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Articles linked to this work by shared authors, journal, and citation graph.

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Association between locomotor muscle quality and cardiac function during exercise in heart failure with preserved ejection fraction.

European journal of heart failure·2024
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Tirzepatide Reduces LV Mass and Paracardiac Adipose Tissue in Obesity-Related Heart Failure: SUMMIT CMR Substudy.

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Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity.

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Effects of Tirzepatide on the Clinical Trajectory of Patients With Heart Failure, Preserved Ejection Fraction, and Obesity.

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Effects of tirzepatide on circulatory overload and end-organ damage in heart failure with preserved ejection fraction and obesity: a secondary analysis of the SUMMIT trial.

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Related Experiment Video

Updated: Aug 7, 2025

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

6.5K

Heart Failure With Preserved Ejection Fraction: A Review.

Margaret M Redfield1, Barry A Borlaug1

  • 1Department of Cardiovascular Disease, Division of Circulatory Failure, Mayo Clinic, Rochester, Minnesota.

JAMA
|March 14, 2023
PubMed
Summary
This summary is machine-generated.

Heart failure with preserved ejection fraction (HFpEF) affects millions globally. First-line treatments include SGLT2 inhibitors, exercise, and self-care, improving outcomes for this common condition.

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Related Experiment Videos

Last Updated: Aug 7, 2025

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
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Area of Science:

  • Cardiology
  • Heart Failure Research
  • Clinical Medicine

Background:

  • Heart failure with preserved ejection fraction (HFpEF) impacts 3 million in the US and 32 million worldwide, with high hospitalization and mortality rates.
  • Key risk factors include older age, hypertension, diabetes, dyslipidemia, and obesity.
  • Patients often present with dyspnea, with or without overt congestion, necessitating accurate diagnostic approaches like the H2FPEF score.

Approach:

  • Diagnosis involves assessing clinical factors, resting hemodynamics, and ruling out other cardiac conditions.
  • Utilizing the H2FPEF score aids in diagnosing HFpEF in patients with unexplained dyspnea.
  • Identifying and treating specific underlying causes like valvular or pericardial disease is crucial.

Key Points:

  • First-line pharmacologic therapy includes sodium-glucose cotransporter type 2 inhibitors (e.g., dapagliflozin, empagliflozin), demonstrating a 20% reduction in HF hospitalizations or cardiovascular death.
  • Non-pharmacologic interventions like exercise training and weight loss improve functional capacity and quality of life.
  • Diuretics are used for symptom management in patients with overt congestion.

Conclusions:

  • HFpEF management requires a multi-faceted approach including pharmacotherapy, lifestyle modifications, and patient education.
  • Sodium-glucose cotransporter type 2 inhibitors represent a significant advancement in HFpEF treatment.
  • Comprehensive self-care education is vital for preventing decompensation and improving patient outcomes.