Related Experiment Video

Updated: Aug 6, 2025

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
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Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

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Refractory corticotroph adenomas

Amit K S Sumal1, Dongyun Zhang1, Anthony P Heaney2,3

  • 1Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.

Pituitary
|March 14, 2023
PubMed

Insights

Refractory corticotroph adenomas are challenging tumors that often recur and resist treatment. Current molecular insights are insufficient to guide therapy, necessitating new diagnostic tools and treatments.

Area of Science:

  • Endocrinology
  • Oncology
  • Molecular Biology

Background:

  • Corticotroph adenomas are pituitary tumors, mostly benign.
  • Some adenomas are locally invasive, recurrent, and resistant to standard treatments (surgery, radiation, medication).

Purpose of the Study:

  • To review somatic and genetic mutations and molecular factors in corticotroph adenoma pathogenesis.
  • To discuss current therapeutic strategies for these tumors.

Main Methods:

  • Literature review of molecular studies on corticotroph adenomas.
  • Analysis of current treatment options and their efficacy.

Main Results:

  • Molecular studies have improved understanding of corticotroph adenoma behavior.
  • Current molecular insights do not reliably inform treatment decisions.

Conclusions:

  • Novel diagnostic tools and targeted therapies are required for refractory corticotroph adenomas.
  • Further research is needed to develop more effective treatment options for patients with these challenging tumors.
Keywords:
Refractory corticotroph adenomas

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