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Published on: March 24, 2023
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Patch Testing With Benzophenone-3 and -4: The North American Contact Dermatitis Group Experience, 2013-2020.
Erin M Warshaw1,2,3, Michelle Xiong1,4, Donald V Belsito5
1From the Department of Dermatology, Park Nicollet/Health Partners Health Services, Minneapolis, Minnesota, USA.
Dermatitis : Contact, Atopic, Occupational, Drug
|March 14, 2023
Summary
Benzophenone-3 and Benzophenone-4 are common UV filters that can cause allergic reactions. A study found 2.1% of patients had positive reactions, often linked to sunscreens and personal care products.
Area of Science:
- Dermatology
- Allergology
- Cosmetic Science
Background:
- Benzophenone-3 (BZP-3) and Benzophenone-4 (BZP-4) are widely used UV filters in sunscreens and personal care products.
- These compounds are known to potentially cause allergic contact dermatitis.
Purpose of the Study:
- To determine the prevalence of positive patch test reactions to BZP-3 and BZP-4.
- To analyze clinical relevance and common sources of exposure for benzophenone allergies.
Main Methods:
- Retrospective analysis of patch test data from the North American Contact Dermatitis Group (2013-2020).
- Inclusion of 19,618 patients tested with BZP-3 (10% pet) and BZP-4 (2% pet).
Main Results:
- Overall prevalence of benzophenone positivity was 2.1% (413/19,618 patients).
- BZP-positive patients showed higher rates of hay fever, atopic dermatitis, and facial involvement.
- Most reactions were clinically relevant, with sunscreens and personal care products identified as common sources.
Conclusions:
- The 8-year prevalence of benzophenone allergy is 2.1%, primarily associated with cosmetic products.
- Benzophenone allergies are frequently clinically relevant and linked to specific patient demographics and product usage.
