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Applications of Volumetric Absorptive Microsampling Technique: A Systematic Critical Review

Prerna Dodeja1, Spiros Giannoutsos2, Steve Caritis3

  • 1Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh.

Therapeutic Drug Monitoring
|March 14, 2023
PubMed
Summary

Volumetric Absorptive microsampling (VAMS) offers improved precision for measuring drug concentrations compared to dried blood spots. This microsampling technique is ideal for pharmacokinetic studies, especially in special populations.

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Sampling materials are classified into three main types: solid, liquid, and gas.
Solid samples include a variety of substances, such as sediments from water bodies, soil, metals, and biological tissues. Two standard methods for extracting sediments from water bodies are grab sampling and piston coring. Grab sampling involves using a device to collect a discrete sediment sample from the bottom of a water body with minimal disturbance. Grab samples do not always represent the entire area due to...
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Volatilization gravimetry is an analytical technique that measures the mass lost due to the volatilization of the substance. This technique is used to estimate the amount of volatile material in a sample. To perform this method, heat a known amount of the sample to a high temperature in a crucible or other suitable vessel. The volatile substance in the sample evaporates, and the vapor is completely expelled from the crucible either by heating the sample or bubbling a stream of inert gas through...
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