Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Engineering the esophagus: advances, challenges, and translational pathways in esophageal tissue reconstruction.

Biofabrication·2026
Same author

Electroconductive Soft Microcarriers for Suspension Culture of Skeletal Muscle Cells.

Macromolecular bioscience·2026
Same author

CAR-T Cell-Derived Exosomes and Cancer Immunotherapy: Advancing Production and Delivery Through Biofabrication.

Biofabrication·2026
Same author

Age-related increase in plasma p-tau217 in amyloid-beta-negative cognitively unimpaired individuals affects diagnostic interpretation.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Clinical study: Cardiovascular outcomes after a 14-week exercise intervention in young adults born preterm.

Pediatric research·2026
Same author

The long-term impact of retinopathy of prematurity on retinal function assessed with new patterns of mfERG analysis.

Documenta ophthalmologica. Advances in ophthalmology·2026

Related Experiment Video

Updated: Aug 6, 2025

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer
07:05

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer

Published on: September 22, 2015

10.1K

A handheld bioprinter for multi-material printing of complex constructs.

Erik Pagan1, Evan Stefanek1, Amir Seyfoori1

  • 1Laboratory for Innovations in Microengineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria BC V8P 5C2, Canada.

Biofabrication
|March 14, 2023
PubMed
Summary
This summary is machine-generated.

A new handheld bioprinter enables precise in situ bioprinting for tissue repair. This versatile device fabricates multi-component fibers for drug delivery, biosensors, and modeling cancer cell invasion with high cell viability.

Keywords:
bioinksbioprintingcell deliverydrug deliveryin situ printing

More Related Videos

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink
08:34

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

Published on: April 21, 2016

16.8K
Automated Robotic Dispensing Technique for Surface Guidance and Bioprinting of Cells
10:14

Automated Robotic Dispensing Technique for Surface Guidance and Bioprinting of Cells

Published on: November 18, 2016

7.3K

Related Experiment Videos

Last Updated: Aug 6, 2025

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer
07:05

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer

Published on: September 22, 2015

10.1K
Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink
08:34

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

Published on: April 21, 2016

16.8K
Automated Robotic Dispensing Technique for Surface Guidance and Bioprinting of Cells
10:14

Automated Robotic Dispensing Technique for Surface Guidance and Bioprinting of Cells

Published on: November 18, 2016

7.3K

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Materials Science

Background:

  • In situ bioprinting offers site-specific delivery of pro-healing constructs for tissue repair.
  • Printing multiple materials simultaneously or sequentially allows for tissue biomimicry.
  • Existing bioprinting technologies often lack portability and precise control over material properties.

Purpose of the Study:

  • To develop a novel, low-priced, modular handheld bioprinter for in situ bioprinting.
  • To demonstrate the fabrication of shape-controlled, multi-component fibers with controlled properties.
  • To explore the applications of the bioprinted fibers in drug delivery, biosensing, and cancer modeling.

Main Methods:

  • Integration of stereolithography 3D printing and microfluidic technologies.
  • Development of an ergonomic handheld bioprinter for controlled biofabrication.
  • Incorporation of drug-loaded microcarriers, conductive materials, and pH-responsive dyes into bioinks.

Main Results:

  • Successful fabrication of multi-component fibers with diverse cross-sectional shapes and material compositions.
  • Demonstration of on-demand, temporal, and dosage-controlled drug delivery using printed fibers.
  • Creation of functional biosensors, wearable electronics, and cell-laden fibers with high cell viability.
  • Modeling of cancer cell invasion into adjacent tissues using multi-component cell-laden fibers.

Conclusions:

  • The developed handheld bioprinter provides exquisite control over bioink properties for in situ applications.
  • The platform offers versatile applications in regenerative medicine, drug delivery, and wearable technology.
  • This technology facilitates site-specific cell delivery and advanced tissue modeling, including cancer invasion.