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Potential antitumor agents. II. Lappin intramolecular cyclization of diethyl 3-carbazolylaminomethylenemalonate: a
F Corelli1, S Massa, G Stefancich
1Istituto di Chimica Farmaceutica e Tossicologica, Facoltà di Farmacia, Università degli Studi di Roma, La Sapienza, Italy.
Il Farmaco; Edizione Scientifica
|September 1, 1987
Abstract:
Diethyl 3-carbazolylaminomethylenemalonate undergoes Lappin cyclization giving 2-carbethoxy-1-oxo-1,4-dihydro-7H-pyrido[2,3-c]carbazole. Formation of an angular pyridocarbazole derivative is consistent with the Markwald rule. The synthesis of 4-ethyl derivatives of the above pyridocarbazole and its 8,9,10,11-tetrahydro derivative is also reported as a goal to potential indoloquinolone antitumoral agents.