Related Experiment Videos
Multiple effects of alpha-toxins on the nicotinic acetylcholine receptor
R J Bradley1, M K Pagala, M T Edge
1Neuropsychiatry Research Program, School of Medicine, University of Alabama at Birmingham 35294.
FEBS Letters
|November 30, 1987
Abstract:
Very low concentrations (5 nM) of alpha-toxin from the venom of Naja naja atra produced a characteristic fade in muscle compound action potential and tetanus induced by repetitive nerve stimulation which was identical to the effects of curare. High concentrations of alpha-toxin and all concentrations of alpha-bungarotoxin reduced the response but produced very little fade in comparison to curare. These results suggest that alpha-toxins have more than one effect at the neuromuscular junction.