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Impact of pharmacogenetics on aspirin resistance: a systematic review

Gustavo Figueiredo da Silva1, Bruno Mattei Lopes1, Vinicius Moser1

  • 1Universidade da Região de Joinville, Departamento de Medicina, Joinville SC, Brazil.

Arquivos De Neuro-Psiquiatria
|March 14, 2023
PubMed

Insights

Genetic variants impact aspirin resistance (AR), affecting cardiovascular disease (CVD) treatment. Further research is needed to understand these pharmacogenetic associations for improved patient outcomes.

Area of Science:

  • Pharmacogenetics
  • Cardiovascular Disease Research
  • Genetics and Medicine

Background:

  • Pharmacogenetics offers improved disease management, particularly for cardiovascular disease (CVD).
  • Acetylsalicylic acid (aspirin) is crucial for CVD prevention by inhibiting platelet aggregation.
  • Genetic variations can lead to aspirin resistance (AR), causing treatment failure in some patients.

Conclusions:

  • Pharmacogenetics is a rapidly advancing field with significant potential.
  • Further research is essential to elucidate the complex associations between genetic variants and aspirin resistance.
  • Understanding these genetic factors can lead to more personalized and effective CVD prevention strategies.
Abstract

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