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Dexamphetamine widens temporal and spatial binding windows in healthy participants.
Faiz M Kassim1, Samra Krakonja Lahooti2, Elizabeth Ann Keay2
1From the Department of Psychiatry, St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia (Kassim); the Psychopharmacology Unit, School of Biomedical Sciences, University of Western Australia, Perth, WA, Australia (Kassim, Lahooti, Keay, Martin-Iverson); the Psychiatry, Graylands Hospital, Mt Claremont, Perth, WA, Australia (Iyyalol); the Experimental and Regenerative Neurosciences, School of Biological Sciences, University of Western Australia, Crawley, WA, Australia (Rodger); the Brain Plasticity Group, Perron Institute for Neurological and Translational Science, Nedlands, WA, Australia (Rodger); the Western Australian Centre for Road Safety Research, School of Psychological Science, University of Western Australia, Perth, WA, Australia (Albrecht) faiz.mohammed@sphmmc.edu.et faizphr@gmail.com.
Dexamphetamine, a stimulant, enhanced illusory perception in a tactile illusion, suggesting dopamine influences sensory processing windows. This research aids understanding psychosis pathophysiology and sensory binding mechanisms.
Area of Science:
- Neuroscience
- Psychopharmacology
- Sensory Perception
Background:
- Psychosis pathophysiology involves complex mechanisms, with stimulus binding windows (BWs) offering potential insights.
- Dopamine release is linked to psychosis and widened BWs.
- Investigating catecholamine system manipulation can probe BW mechanisms relevant to psychosis.
Purpose of the Study:
- To investigate the effect of dexamphetamine, a dopamine-releasing stimulant, on BWs.
- To examine how manipulating dopamine/catecholamine systems impacts psychosis and BWs.
- To assess dexamphetamine's effect on the tactile funneling illusion (TFI).
Main Methods:
- A randomized, double-blind, placebo-controlled crossover study was conducted.
- 46 participants received dexamphetamine (0.45 mg/kg).
- The TFI was manipulated across 5 spatial (1-5 cm) and 3 temporal (0, 500, 750 ms) conditions.
Main Results:
- Dexamphetamine significantly increased the funnelling illusion (p = 0.009).
- Errors in localization increased with dexamphetamine in a delay-dependent manner (p = 0.03).
- A significant interaction effect showed increased localization error at 500 ms temporal and 4 cm spatial separation (p_interaction = 0.009).
Conclusions:
- Dexamphetamine enhances illusory perception in the unimodal TFI in healthy individuals.
- Findings suggest dopamine or other catecholamines play a role in expanding tactile spatial and temporal BWs.
- This supports amphetamine-induced models for studying dopamine's role in psychosis and sensory processing.
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